Actor Gene Hackman stars as Detective Jimmy "Popeye" Doyle in the 1971 thriller The French Connection. The film was directed by William Friedkin. The character was based on a real-life cop named Eddie Egan, whose nickname was "Popeye" in real life.
Popeye the Sailor, the *original* Popeye, was a cartoon character first created in 1929. Admittedly, the two characters really have nothing to do with each other, except for the common name and extreme pugnacity in both cases.